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Toxicology Position Papers and White Papers

A compilation of papers written by the TCEQ Toxicology Division.

Files linked from this page are in Portable Document Format (PDF) Adobe Acrobat PDF Document. (Help with PDF.)



Approaches to Derive Odor-Based Values

This position paper Adobe Acrobat PDF Document was included as Section 2.2 of the 2015 updated RG-442 Adobe Acrobat PDF Document.

The Texas Commission on Environmental Quality revised Section 2.2, Odor-Based ESLs, of Guidelines to Develop Toxicity Factors (publication RG-442) (TCEQ 2012). This position paper was developed to describe how TCEQ toxicologists (1) evaluate available chemical-specific data for chemicals proposed for derivation, and (2) conduct analysis to determine whether development of an odor-based value is needed to prevent odor nuisance conditions. The TCEQ sought public comments on this position paper and a proposed odor ESL list and received several comments. The response to public comments Adobe Acrobat PDF Document addresses comments received on both of these documents. The list Microsoft Excel represents the substances that the TCEQ has determined have a need for an odor value (i.e., these substances are a product of following the position pape.

Please refer to the Published ESL List to see which value is to be used for permitting purposes (i.e., odor or short-term health).


TCEQ Guidelines to Develop 24-Hour Inhalation Reference Values

This white paper Adobe Acrobat PDF Document was included as section 4.6 in the 2015 updated RG-442. Adobe Acrobat PDF Document

Updated Recommendations for Animal-to-Human Inhalation Dosimetry

This white paper Adobe Acrobat PDF Document was updated in section 3.9.1 in the 2015 updated RG-442 Adobe Acrobat PDF Document.

The Toxicology Division  amended Section 3.9.1, “Default Dosimetry Adjustments for Gases,” in the October 2012 version of RG-442 to include information on animal-to-human inhalation gas-dosimetric adjustments based on recommendations in Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment (U.S. EPA 2012, EPA/600/R-12/044). Please refer to the white paper for a discussion of the changes.

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